BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME

Sergo Vashakidze

POSITION TITLE

Coordinator of Surgical Work at the National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia

eRA COMMONS USER NAME

 

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE

(if applicable)

YEAR(s) FIELD OF STUDY
Tbilisi State Medical University M.D. 1980 Medicine
Tbilisi State Medical University PhD 1987 Medicine
Tbilisi State Medical University SciD 1995 Medicine

 

A. Areas of Interest:

 

General Thoracic Surgery, surgery of pulmonary tuberculosis, videothoracoscopic and videoassisted thoracic surgery, bronchology field, surgery of mediastinum and chest wall, development and introduction of new methods of thoracic surgery, in particular electrochemical lysis, management of MDR-TB…

 

Academic & Professional Qualifications:

2011-2014 NIH Fogarty International Center Research Fellow, Emory University, Atlanta, GA, USA

2009 Course in Videothoracoscopy, Lungenklinik, Berlin, Germany

2009 Qualification in Thoracic Surgery field and Multidrug Resistant Tuberculosis Management,

State Agency of Tuberculosis Control, Riga, Latvia

2006 Qualification in Thoracic Surgery, State Agency of Tuberculosis Control, Riga, Latvia

2004 Qualification in Thoracic Surgery, Department of Thoracic Surgery, Hospital of Chinese-Japanese Friendship, Beijing, China

1995 Defended Doctoral Thesis, Tbilisi State Medical University, Georgia

1988 Qualification in Thoracic Surgery Department, Central Tuberculosis Scientific Institute, Moscow, Russian Federation

1987 Defended a Candidate Thesis, Tbilisi State Medical University, Georgia

1982-1986 PhD Fellowship, Tbilisi State Medical University, Georgia

1980-1982 Clinical Ordinature course in Thoracic Surgery Field, Tbilisi State Medical University, Georgia

 

  1. Positions and Honors

 

Positions and Employment

 

1982-87 Surgeon, Thoracic Surgery Department of Tuberculosis and Lung Diseases, Tbilisi, Georgia

1987-2001 Head, Thoracic Surgery Department of Scientific Research Institute of Tuberculosis and Lung Diseases

1992-1995 Assistant Professor of Surgery, Tbilisi State Medical University

2001-present Coordinator of Surgical Work at the National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia

2002-2006 Professor of Surgery, Javakhshvili State University, Tbilisi, Georgia

2004-2009 Electrochemical Therapy Clinical Director

2006-2008 Professor of Surgery, David the Builder University, Tbilisi, Georgia

2008-2010 Head of Surgery Department, Pipia Tbilisi Medical Institute

2011-2013 NIH Fogarty International Center Research Trainee

 

Other Experience and Professional Memberships

1982-present Member, Surgical Association of Georgia

1997-present Vice-president of Phthisologists and Pulmonologists Association of Georgia

2010-present Member, European Society of Thoracic Surgeons

2010-present Member, International Union Against Tuberculosis and Lung Diseases

2011 – Present Member of the International Chest Wall Interest Group (CWIG)

 

  1. Selected Peer-reviewed Publications:

1.Vashakidze S L. Kupreishvili, Clinical importance of prostaglandins and cyclic nucleotides investigation at pulmonary pathology. III Georgian Rheumatology Congress, Tbilisi, 2000, p26-31

2.Vashakidze S, L. Kupreishvili, M.Nonikashvili, Clinical and Pathogenic aspect of renin-aldosterone system in pulmonary operations. Transactions of Tbilisi State Medical University, 2001, vol. XXX I, pp.162-11169

3.Vashakidze S, M. Japaridze. Levomecole application at tuberculosis empyema. Transactions of Tbilisi State Medical University, 2004, vol. 48, pp.104-111

  1. Vashakidze S L.Mskhiladze, N.Shubladze, K.Apridonidze M.tuberculosis cultural diagnostics optimization in Georgia // Proc. Georgian Acad.Sci.,biol.Ser. A, 2005, # 6, Vo31, ,pp. 865-871
  2. Vashakidze S L.Mskhiladze, N.Shubladze, K.Apridonidze M.tuberculosis cultural diagnostics optimization in Georgia // Proc. Georgian Acad.Sci.,biol.Ser. A, 2005, # 6, Vo31, ,pp. 865-871

6.Vashakidze S, Gogishvili Sh, Lursmanashvili G. Meaning of Surgery in Treatment of Resistant forms of Lung Tuberculosis”. Interactive Cardiovascular and Thoracic Surgery journal, vol. 9, suppl. 1, 2009

  1. Vashakidze S, Kempker RR, Solomonia N, Dzidzikashvili N, Blumberg HM. Surgery in drug-resistant tuberculosis. Lancet Infect Dis 2012; 12:157-66
  2. 8. Vashakidze S, Kempker RR, Rabin AS, Nikolaishvili K, Blumberg HM, Additional drug resistance in Mycobacterium tuberculosis isolates from resected cavities among pulmonary M/XDR-TB Clinical Infectious Diseases 2012;1:144-151
  3. Vashakidze S, Gogishvili Sh, Nikolaishvili K, Dzidzikashvili N, Tukvadze N, Blumberg HM, Kempker R, Favorable Outcomes for Multidrug and Extensively Drug Resistant Tuberculosis Patients Undergoing Surgery. Ann Thorac Surg 2013;95:1892–8
  4. 10. Lomtadze N,Kupreishvili L,Salakaia A, Vashakidze S, Sharvadze L, Kempker R, Magee M, Del Rio C, Blumberg H
    Hepatitis C Virus Co-Infection Increases the Risk of Anti-Tuberculosis Drug-Induced Hepatotoxicity among Patients with Pulmonary Tuberculosis. PLoS ONE 01/2013; 8(12):e83892.
  5. 11. Vashakidze L,Kiria N, .Vashakidze S and all. National Guidelines for managements of tuberculosis;Tbilisi, Georgia;2013
  6. 12. Vashakidze S, National protocol for surgery of tuberculosis;Tbilisi,Georgia; 2013
  7. 13. Russell R Kempker,Aline B Barth,Sergo Vashakidze, Ketino Nikolaishvili, Irina Sabulua, Nestani Tukvadze, Nino Bablishvili, Shota Gogishvili, Ravi Shankar P Singh, Jeannette Guarner, Hartmut Derendorf, Charles A Peloquin, Henry M Blumberg. Cavitary penetration of levofloxacin among patients with multidrug-resistant tuberculosis.

Antimicrob Agents Chemother 2015 16;59(6):3149-55. Epub 2015 Mar 16.

  1. 14. Sergo Vashakidzea,Albert Despuigb,c, Shota Gogishvilia Keti Nikolaishvilia, Natalia Shubladzea, Zaza Avaliania, Nestan Tukvadzea, Martí Casalsd, e, Joan A. Caylàd, e, Pere-Joan Cardonab, c, Cristina Vilaplanab, c, , Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia
  2. Nestani Tukvadze a , Paula Cardona b , Sergo Vashakidze , Natalia Shubladze a , Zaza Avaliani a , Cris Vilaplana b , Pere-Joan Cardona b, Development of the food supplement Nyaditum resae as a new tool to reduce the risk of tuberculosis development,International journal of Mycobacteriology

 

  1. Oral and poster presentations:

1.1-st International Joint meeting on Thoracic Surgery, Poster, Barcelona, Spain,2009. “Current Role of Surgery In the Lung Tuberculosis Treatment”Oral Prezentation, Authors Vashakidze S, Gogishvili Sh,

2.17-th European Conference on General Thoracic Surgery, Krakow, Poland,2009, Meaning of Surgery in Treatment of Resistant forms of Lung Tuberculosis”. Poster, Authors Vashakidze S, Gogishvili Sh, Lursmanashvili G

3.5-th Congress of the International Union Against Tuberculosis and Lung Disease, Europe Region, Dubrovnik, Croatia,2009” Clintical Importance of Mycobacterium tuberculosis drug resistance in lung resectates from pulmonary TB patients” Poster, Authors S.Vashakidze,L.Mskiladze,I. Khurtsilava,J.E.Graham, N.Shubladze,L.Kupreishvili, K.Nikolaishvili

4.42nd Union World Conference on Lung Health, Lille, France,2011” Increased risk of antituberculosis drug-induced hepatotoxicity ; ”Oral Presentation, Authors: Kupreishvili L ,Lomtadze N, Salakaia A,Kalandadze I,Vashakidze S,Sharvadze L,Del Rio, Blumberg HM;

5.42nd Union World Conference on Lung Health, Lille, France,2011” Surgery for Patients with Drug Resistant Tuberculosis in the Setting of DOTS Plus: A Report of 80 Patients from Georgia; ”Poster, Authors: Vashakidze S, Gogisvhil Sh, Nikolaishvili K, Dzidzikashvili N,Tukvadze N, H. Blumberg H.M., Kempker R.R.

6.5-th International Conference on Tuberculosis and Lung Diseases, Oral presentation, Baku, Azerbaijan,2011” the Role of surgery in the treatment of pulmonary tuberculosis” Oral presentation, Authors: Vashakidze S

7.Emory-Georgia Fogarty Conference; June 16th,2011;Tbilisi,Georgia, Oral presentation; “Adjuvant Surgical Resection for M/XDR-TB”; Author S.Vashakidze;

8.Emory-Georgia Fogarty Conference; June 25th,2012;Kvareli,Georgia, Oral presentation; “Favorable Outcomes for Highly Drug Resistant Pulmonary Tuberculosis Patients Undergoing Adjunctive Surgery”; Author Vashakidze S;

9.43-rd Union World Conference on Lung Health, Kuala Lumpur, Malaizia, 2012 “Favorable Outcomes for Highly Drug Resistant Pulmonary Tuberculosis Patients Undergoing Adjunctive Surgery”,Poster, Authors: Vashakidze S, Gogisvihil Sh, Nikolaishvili K, Dzidzikashvili N,Tukvadze N, Blumberg H.M., Kempker R.R.

10.Training and re-training for TB doctors including that using standard DOTS modules and DR-TB training GPIC (Global Projects Implementation Center), Tbilisi,Georgia, December,2012,” Role of surgery in the M/XDR – TB management.”Oral presentation, Author: Vashakidze S.

11.”New treatments and approaches to Tuberculosis”, Tuberculosis Symposium-Eastern Europe and Central Asia RA Ministry of Health and Medecins Sans Frontieres,Yerevan, Armenia,February, 2015, “Role of Surgery in Treatment of Patients with MDR/XDR Pulmonary Tuberculosis-Experience from Georgia”, Oral presentation, Author: Vashakidze S.

12.TB Conference; March23th,Tbilisi,Georgia, 2015 “Results of surgical treatment of patients with MDR/XDR tuberculosis”; Oral presentation, Oral presentation, Authors: Vashakidze S, Gogisvihil Sh, Nikolaishvili K, Dzidzikashvili N,Tukvadze N, Nonikashvili M, Blumberg H.M., Kempker R.R.

13.TB Conference; March23th,Tbilisi,Georgia,2015, “Cavitary Penetration of Levofloxacin among Patients with Multidrug Resistant Tuberculosis”; Oral presentation, Authors: Vashakidze S, Gogisvihil Sh, Kempker R,Darth A, Nikolaishvili K,Sabulua I,Tukvadze N, Bablishvili N,Nonikashvili M, Ravi Shankar.Singh, Guarner J,Derendorf H,Peloquin Ch,Blumberg H.M

  1. Conference; March23th,2015;Tbilisi,Georgia,2015,”Preoperative and Postoperative Evaluation of Pulmonary Function in Patients with Multi and Extensively Drug-resistant Pulmonary Tuberculosis Poster,Authors:Jacobia N,Gogishvili Sh,Vashakidze S,Kuchuhidze T,Goginashvili L, , Blumberg H.M., Kempker R.R.

15.Emory-Georgia Fogarty Conference; June24- 26th,2015;Kazbegi,Georgia, Oral presentation, “Role of Surgery in Patients with Drug Resistant Tuberculosis”; Oral presentation, Author Vashakidze S;

16.International Tuberculosis Portals Consortium, December 8-9,Tbilisi ,Georgia, “Georgia TB Portal”, Oral Presentation, Authors:Shubladze N, Vashakidze S, Nanava U

16.International Conference: Corellating Clinical and Experimental TB Pathology”, Costa Bravo, Spain, 2016. ” Surgical approaches in Tbilisi, Georgia to treat TB patients”, Oral Presentation Authors: Vashakidze S,Shubladze N

 

E. Training activities

1.The 10-th International Jordanian Conference of Internal Medicine,Amman,Jordan,2010

2.19-th European Conference on General Thoracic Surgery, Marseilles, France,2011

3.The English classes (from, July 2011-present

4.All forms of TB, including drug-resistant TB to ensure universal access to quality diagnosis and treatment” (grant # GEO-T-GPIC)-Trainer, 2011-present

5.In-country ethics trainings (mentor Givi Javashvili.)-2011,2012,2013,2014,2015, 2016

6.Online ethics training CITI certificate-2012, 2014

  1. Long-distance Learning Scientific and Writing course -2012

8.Project Title: Improving early detection of suspected pulmonary and extra-pulmonary TB cases in multi-profile medical Facilities”USAID (Tuberculosis prevention project), URC facilitiesContract Number: FY2013-G03-7003-Trainer, 2013-present

9.21st European Conference on General Thoracic Surgery, May 26-29, 2013, ICC Birmingham, United Kingdom

10.34th Annual Congress of the European Society of Mycobacteriology (ESM) taking, Florence, Italy, from June 30 until July 3, 2013.

11.V International Conference on Environmental, Industrial and Applied Microbiology , Bio MicroWorld2013, Madrid (Spain), 2-4 October 2013

12.22st European Conference on General Thoracic Surgery, June 15-19, 2014, ICC Copenhagen, Denmark

  1. 23-rdEuropean Conference on General Thoracic Surgery, MayJune , 2015, ICC Lisbon, Portugal

14.Emory-Georgia Fogarty Conference; June23- 25th,2016,Borjomi, Georgia,

  1. 24-rdEuropean Conference on General Thoracic Surgery, MayJune , 2016, ICC Naples, Italy

 

F. Current research project(s) and mentor(s)

NIH K23, Kempker (PI), 2013-present

Pharmacokinetics and Resistance in MDR TB (PHARM TB), Intracavitary Drug Levels and Drug Resistance in Tuberculosis

Role: Resacher

 

ISTC Project:Title: Expanding global knowledge of tuberculosis by establishing the Georgia Tuberculosis Portal, Vashakidze,(PI),2015-2016

NIH K21, Kempker (PI), 2016

International Project :“Study of TB lesions obtained in surgery: in search of best biomarkers correlating with TB pathology, clinical features, MDR cases and prognostic”, Vashakidze,(PI), 2016

 

Research Support

Completed Research Support

 

US CRDF, Cynamon (PI)
Multiple –Drug Resistant Tuberculosis: Epidemiologic, Diagnostic, and Therapeutic Research Opportunities August30-September 1, 2004

Goal: Develop opportunities for collaboration on clinical research projects focusing on tuberculosis, particularly MDR TB infection
Role: In Country PI.

 

US CRDF, Graham (PI)

Characterization of Mycobacterium Tuberculosis Gene Expression Patterns During Growth in the Human Lung

March 2006- March 2008

Goals: to use a genetic analysis methods to analyze global patterns of bacterial gene expression in naturally infected human lung tissue.

Role: In Country PI

 

US CRDF, Blumberg (PI), 2007-2010
Role of Hepatitis C Virus (HCV) as a Risk Factor For Antituberculosis Drug-induced- Hepatotoxicity
The goal of this study was to determine the rates of Hepatitis C co-infection among pulmonary TB patients in the country of Georgia and if HCV co-infection was associated with increased risk of hepatoxicity from anti-mycobacterial medications.
Role: Co-investigator

 

PNNL-T2-0309-GE, Rainina (PI), 2011-2013

Bacteriophages-Based Approaches to Combat Biofilm-Forming Microbes,

Role: In Country PI

 

A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo‑Controlled Study to Assess the Efficacy and Safety of Intercostal Nerve Block with Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy ,2013.02-2013.07

Role: Reseacher

 

Non-Cystic Fibrosis Bronchiectasis A Phase 3, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo‑Controlled Study,2015-2016

Role: Subinvestigator;